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B-11 in the form of Boron Trifluoride Gas for Semiconductor Manufacture
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O-17 in the form of water and gas for Magnetic Resonance Imaging (MRI) and Scientific Applications
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Newsletter 2017 first page small

For information about our Imaging products and activities, please download our new ISMRM 2017 Newsletter.

Our new ISMRM 2018 Newsletter will be available at our booth 604 at this year’s ISMRM in Paris.

ISMRM Newsletter nur Front

For further information about our Imaging products and activities, please download our new ISMRM 2018 Newsletter.

Homepage front

We are very pleased and proud to present our Newsletter from the ISMRM 2019 in Montreal. For further information about our Imaging products and activities, please download our new ISMRM 2019 Newsletter.

Our ISMRM rubber duck family

Due to the great interest in our rubber ducks, which were our giveaways on the previous ISMRM exhibitions (International Society for Magnetic Resonance in Medicine), we decided to display our duck family here.

The rubber ducks are not for sale and only available on the ISMRM at our booth. Next opportunity, ISMRM in Sydney, 2020

Oxygen-17 Bibliography

ISMRM 2018 abstract/presentations

  1. Sebastian C. Niesporek, Reiner Umathum, Jonathan M. Lommen, and Armin M. Nagel; Direct Partial Volume Corrected CMRO2 Determination: Simulation assisted Dynamic 17O-MRI; Abstract #2955
  2. Dmitry Kurzhunov, Jan Sedlacik, Robert Borowiak, Divya Sanam Bolar, Johannes Fischer, Ali Caglar Özen and Michael Bock, Quantification of Oxygen Metabolism in Human Brain: Comparison of Direct 17O with Indirect 1H MR Method. Abstract #3689
  3. Victor D. Schepkin, Andreas Neubauer, Christian Schuch, Tilo Glaeser, Michael Kievel, Steven L. Ranner, William W. Brey, Shannon Helsper, and Lothar Schad; The first observation of 17O MRI in normal rats at 21.1 T; Abstract #4546

ISMRM 2017 abstracts/presentations

  1. Sebastian C. Niesporek, Reiner Umathum, Jonathan M. Lommen, and Armin M. Nagel; Direct Partial Volume Corrected CMRO2 Determination: Simulation assisted Dynamic 17O-MRI; Abstract #2955
  2. Victor D. Schepkin, Andreas Neubauer, Christian Schuch, Tilo Glaeser, Michael Kievel, Steven L. Ranner, William W. Brey, Shannon Helsper, and Lothar Schad; The first observation of 17O MRI in normal rats at 21.1 T; Abstract #4546
  3. Hannes Michel Wiesner, Dávid Zsolt Balla, Klaus Scheffler, Kamil Ugurbil, Xiao-Hong Zhu, Wei Chen, Kamil Uludag, and Rolf Pohmann; Simultaneous measurement of metabolic rates of oxygen via 17O NMR imaging in brain and muscle tissue of rat at 16.4T; Abstract #5623
  4. Dmitry Kurzhunov, Robert Borowiak, Marco Reisert, Axel Joachim Krafft, and Michael Bock; DIrect EStimation of 17O MR ImageS (DIESIS) for CMRO2 Quantification in the Human Brain with Partial Volume Correction; Abstract #0488
  5. Dmitry Kurzhunov, Robert Borowiak, Marco Reisert, Axel Joachim Krafft, Ali Caglar Özen and Michael Bock; 3D CMRO2 Mapping in Human Brain with Direct 17O-MRI: Comparison of Methods for Image Reconstruction and Partial Volume Correction; Abstract #3602
  6. Dmitry Kurzhunov, Robert Borowiak, Ali Caglar Özen, and Michael Bock; CMRO2 Quantification in Human Brain with Direct 17O-MRI: Profile Likelihood Analysis for Optimization of Temporal Resolution; Abstract #0568
  7. Robert Borowiak, Wilfried Reichardt, Dmitry Kurzhunov, Christian Schuch, Benjamin Görling, Dieter Leibfritz, Jochen Leupold, Thomas Lange, Helge Haas, Jens Timmer, and Michael Bock; Quantification of Cerebral Metabolic Rates of 17O-Labeled Glucose in Mouse Brain with Dynamic 17O-MRS; Abstract #2954
  8. Hannes Michel Wiesner, Yi Zhang, Ming Lu, Nanyin Zhang, Xiao-Hong Zhu, and Wei Chen; Measurement of CMRO2 in conscious rat with in vivo 17O MRS at 16.4T; Abstract #2953

ISMRM 2016 abstracts/presentations

  1. Dmitry Kurzhunov, Robert Borowiak, Marco Reisert, Philipp Wagner, Axel Krafft, and Michael Bock; 3D CMRO2mapping in human brain with direct 17O-MRI and proton-constrained iterative reconstructions; Program Number 1470
  2. Hannes Michel Wiesner, Xiao-Hong Zhu, Kamil Ugurbil, and Wei Chen; Sensitivity Comparison of Ultrahigh-field Oxygen-17 MRS Imaging between 7T and 10.5T using a Human Head Size Phantom and Quadrature Surface Coil; Program Number: 3942
  3. Ruomin Hu, Andreas Neubauer, Jorge Chacón-Caldera, Javier Uranga Solchaga, Christian Schuch, Tilo Gläser, Cordula Nies, Eric Gottwald, Stefan Giselbrecht, and Lothar R. Schad; In Vitro Oxygen-17 NMR Spectroscopy of Cellular Metabolism at Ultra High Field; Program Number 3963
  4. Robert Borowiak, Wilfried Reichardt, Dmitry Kurzhunov, Christian Schuch, Jochen Leupold, Thomas Lange, Marco Reisert, Axel Krafft, Elmar Fischer, and Michael Bock; Initial investigation of glucose metabolism in mouse brain using enriched 17O-glucose and dynamic 17O-MRS; Program Number 3964
  5. Sebastian C. Niesporek, Reiner Umathum, Thomas M. Fiedler, and Armin M. Nagel; Evaluation of High Temporal and Spatial Resolution 17O-MRI; Program Number 3965
  6. Sebastian C. Niesporek, Reiner Umathum, Thomas M. Fiedler, and Armin M. Nagel; Iterative Approach for Partial Volume Corrected T2* Determination in 17O-MRI; Program Number 3966

ISMRM 2015 abstracts/presentations

  1. Borowiak, R., Kurzhunov, D., Wagner, P.,  Reisert, M., Bock; Dynamic 17O-MRI at 3 Tesla for In Vivo CMRO2 Quantification; Program Number: 4633
  2. Zhang, Y., Erokwu, B. O., Liu, Y., Farr, G. W., Boron, W. F.,  Flask, C. A.,  Yu, X.; Assessing Water Influx and Retention in the Brain of AQP4 Knockout Mice by 17O-MRI; Program Number: 1997.
  3. Najac, C., Tiret, B.,  Flament, J.,  Guillermier, M., Houitte, D.,  Badin, R.A.,  Hantraye, P., Brouillet, E., Lebon, V., Valette, J., CMRO2 Quantification by Direct 17O MRI at 7 T in the Macaque Brain: Assessment of Energy Metabolism Impairment In Vivo; Program Number: 4615.
  4. Zhu, X-H., Wiesner, H. M., Lee, B-Y., Lu, M., Ugurbil, K., Chen, W.; Quantitative and Simultaneous Imaging of CMRO2, CBF and OEF in Resting Human Brain; Program Number: 0895.

ISMRM 2014 abstracts/presentations

  1. Borowiak, R., Groebner, J., Kurzhunov, D., Fischer, E., Dragonu, I., Bock, M.; Direct Cerebral 17O-MRI at a Clinical Field Strenght of 3 Tesla Using a Tx/Rx Head Coil; Program Number: 0687.
  2. Zhu, X-H., Liu, X., Lu, M., Wiesner, H M., Ugurbil, K., Chen, W,; In Vivo 17O MR Imaging and Quantification of CMRO2, CBF and OEF in Human Visual Cortex at Rest and During Activation; Program Number: 3763.
  3. Augath, M A., Seuwen, A., Zwick, S., Rudin, M.; Increase in Sensitivity and Signal Stability in 17O MRI Using a Cryogenic RF Probe; Program Number: 2972.
  4. Möllenhoff, K., Felder, J., Romanzetti, S., Gordji-Nejad, A., Shah, N J., Natural Abundance in Vivo 17O Measurements at 9.4T; Program Number: 0475.
  5. Barbier, E., Mapping Blood Flow & Tissue Oxygenation with MRI: Insights from Other Modalities
  6. Cerdán, S.; Subject: Bamboc; MR Spectroscopy: The Promise; Program Number: 1027.

ISMRM 2013 abstracts/presentations

  1. Romanzetti, S., Fiege, D. P., Shah, N.J., 3D TWIRL: A Novel K-Space Trajectory for Imaging of Fast Relaxing Nuclei; Program Number: 3965.
  2. Hoffmann, S. H., Meise, F. M., Biller, A., Nagel, A. M.; Adaptive Combination of Multichannel Data for Non-Proton MRI; Program Number: 1983.
  3. Groebner, J., Borowiak, R., Rösler, M., Umathum, R., Fischer, E., Pavlina, J. M., Bock, M.; In Vivo 17O-MRI at 3 Tesla Using a TxRx Surface Coil; Program Number: 1985.
  4. Lee, J.-H., Norris, M., Fugate, E. M., Avdievich, G. I., Hetherington, H. P.; A Novel Double Tuned 4T 1H/17O Head Volume Coil; Program Number: 2784.
  5. Cui, W., Zhu, X.-H., Vollmers, M., Colonna, E., Adriany, G., Tramm, B., Dubinsky, J., Oz, G., Oxygen-17 MRS for CMRO2 Measurements in the Mouse Brain at 16.4T; Program Number: 0863.
  6. Hoffmann, S. H., Radbruch, A., Semmler, W., Nagel, A. M.; . Partial Volume Corrected CMRO2 Determination in a Glioblastoma Patient by 17O MRI; Program Number: 0216.
  7. Wang, X., Zhu, X.-H., Zhang, Y., Chen, W., Significant BOLD Signal Reduction Induced by Perfluorocarbon Emulsion in the Rat Brain; Program Number: 0848.
  8. Boros, E., Polasek, M.v., Zhang, Z., Caravan, P.A.; Single Amino Acid Gd-Complex as a Modular Tool for High Relaxivity MR Contrast Agent Development; Program Number: 1900.
  9. Atkinson, I. C., Ultra-High Field MR: Multi-Nuclear Imaging, Symposium – Emerging Technologies for Clinical Neuroimaging; Program Number: 007006

ISMRM 2012 abstracts/presentations

  1. Pilkinton, D. T., Babu, V. K., Baker, W., Greenberg, J. H., Reddy, R., Hyperoxic Calibrated Quantitative fMRI for the Measurement of Regional Cerebral Metabolic Rate of Oxygen in a Hypermetabolic Swine Model; Program; Proc. Intl. Soc. Mag. Reson. Med. 20 (2012); Number: 2912
  2. Zhu, X.-H., Chen, W., In Vivo 17O Measurements of Water Rotational Correlation Time and Hydrodynamic Radius in Rat Brain; Intl. Soc. Mag. Reson. Med. 20 (2012); Program Number: 1821
  3. Wiener, E. C., Sengar, R., Elst, L. V., Abadjian, M.-C., Moore, C.E., Rheingold, A. L., Grotjahn, D., New Bifunctional Chelates with Optimal Water Residence Times for Molecular Imaging; Intl. Soc. Mag. Reson. Med. 20 (2012); Program Number: 0793
  4. Zheng, J., Muccigrosso, D., Bashir, A., Gupte, P., Gropler, R. J.; Quantitative Cardiac 17O MRI: Initial Validation Study; Intl. Soc. Mag. Reson. Med. 20 (2012); Program Number: 3887.
  5. Liu, P., Xu, F., Lu, H.; A Turn-Key Solution for the Quantification of Brain Oxygen Metabolism; Intl. Soc. Mag. Reson. Med. 20 (2012); Program Number: 471.

ISMRM 2011 abstracts/presentations

  1. Atthe B, Kemerer M, Chen Y, et al. Quantitative Assessment of Mitochondrial Metabolic Efficiency by 17O and 31P MR Spectroscopy in Isolated Rat Hearts. Intl. Soc. Mag. Reson. Med. 19 (2011).
  2. Muccigrosso D, He X, Abendschein D, et al. Methods for Quantification of Absolute Myocardial Oxygen Con- sumption with 17O-CMR. Intl. Soc. Mag. Reson. Med. 19 (2011).
  3. Meise FM, Groebner J, Nagel AM, et al. A 30-Channel Phased Array for Oxygen-17 (17O) Brain MRI at 7 Tesla. Intl. Soc. Mag. Reson. Med. 19 (2011).
  4. Hoffmann SH, Nagel AM, Meise FM, Umathum R, Bock M. In Vivo Relaxation Parameters of Oxygen-17 (17O). Proc. Intl. Soc. Mag. Reson. Med. 19 (2011).
  5. Zhu X-H, Chen J, Tu T-W, Chen W, Song S-K. Exploring the New Utility of the 17O-MRS Imaging Technique for Studying CMRO2 and Perfusion in Stroke Mice. Intl. Soc. Mag. Reson. Med. 19 (2011).
  6. Wiesner HM, Pohmann R, Balla DZ, Chen W, Ugurbil K, Uludag K. Measurement of CMRO2 Changes by Soma- tosensory Stimulation in Rat Using Oxygen-17 at 16.4T. Intl. Soc. Mag. Reson. Med. 19 (2011).
  7. Kassey VB, Baker W, Mesquita RC, et al. Preliminary Studies to Assess CMRO2 with Integrated T1 Rho MRI and Hybrid DRS/DCS Optical Approach in Clinical Scanners. Intl. Soc. Mag. Reson. Med. 19 (2011).
  8. Mateescu GD, Flask CA, Duerk JL. Novel Approach for the Assessment of the Bioavailability of Exogenous Phos- phate by in Vivo Dynamic 17O and 31P MRS and MRI. Intl. Soc. Mag. Reson. Med. 19 (2011).
  9. Lu M, Wang X, Taylor R, et al. In Vitro and In Vivo Studies of 17O NMR Sensitivity at 9.4 and 16.4 Tesla. Intl. Soc. Mag. Reson. Med. 19 (2011).
  10. Kirsch S, Schad LR. Single-Slice Mapping of Submillisecond T2 Using Spin Echo Prepared Ultra-Short Echo Time Imaging. Intl. Soc. Mag. Reson. Med. 19 (2011).

ISMRM 2010 abstracts/presentations

  1. Zhu X-H, Zhang Y, Chen W. In Vivo 17O MRS Imaging for Assessing Myocardial Oxygen Metabolism in Rat Heart at 9.4T. Intl. Soc. Mag. Reson. Med. 18 (2010).
  2. Zhu X-H, Zhang Y, Wiesner H, Ugurbil K, Chen W. Estimation of CBF Based on the Metabolic H217O Decay Rate in CMRO2 Measurement Using In Vivo 17O MR Approach. Intl. Soc. Mag. Reson. Med. 18 (2010).
  3. Hoffman S, Begovatz P, Nagel A, Umathum R, Bock M. In Vivo Oxygen-17 (17O) MRI at 7 Tesla. Intl. Soc. Mag. Reson. Med. 18 (2010).
  4. Wey H-Y, Du F, Lin A-L, et al. Indirect 17O MRI Using T1ρ at 11.7 T. Intl. Soc. Mag. Reson. Med. 18 (2010).
  5. Narazaki M, Kanazawa Y, Ikehira H, Matsuda T. The 17O Imaging for Regional Oxygen Consumption Rate in Tumor Bearing Mice at 7T. Intl. Soc. Mag. Reson. Med. 18 (2010)
  6. Lu M, Spires J, Mateescu GD, Flask C, Yu X. Exploration of Mitochondrial Respiration in Isolated Hearts: An Ob- servation from Metabolically Produced H217O Using 17O NMR Spectroscopy. Intl. Soc. Mag. Reson. Med. 18 (2010).
  7. Atkinson IC, Sonstegaard R, Bityou L, Pliskin NH, Thulborn KR. Safety of 17O and 23Na MR Imaging of the Hu- man Brain at 9.4 Tesla. Intl. Soc. Mag. Reson. Med. 18 (2010).

ISMRM 2009 abstracts/presentations

  1. Wiesner HM, Balla DZ, Pohmann R, Chen W, Ugurbil K, Uludag K. 17O T1/T2* Tissue-Relaxation Rates with Anatomical Contrast in the Rat Brain at 16.4 T. Intl. Soc. Mag. Reson. Med. 18 (2010).
  2. Zhu X-H, Zhang Y, Ugurbil K, Chen W. Direct and Noninvasive Measurement of Cerebral Metabolic Rate of ATP in Cat Brain and Its Physiological Implications. Intl. Soc. Mag. Reson. Med. 18 (2010).
  3. McCommis KS, He X, Abendschein DR, Gupte PM, Gropler RJ, Zheng J. New Methods for the Quantification of Myocardial Oxygen Consumption with 17O MRI. Proc. Intl. Soc. Mag. Reson. Med. 18 (2010).
  4. Atkinson IC, Thulborn KR. Non-Invasive, Whole-Brain CMRO2 Mapping of the Human Brain. Intl. Soc. Mag. Reson. Med. 18 (2010).

Reviews

  1. Gordji-Nejad A, Mollenhoff K, Oros-Peusquens AM, Pillai DR, Shah NJ Characterizing cerebral oxygen metabolism employing oxygen-17 MRI/MRS at high fields, Magn Reson Mater Phy 2014; 27:81–93
  2. Zhu XH, Zhang N, Zhang Y, Zhang X, Ugurbil K, Chen W. In vivo 17O NMR approaches for brain study at high field. NMR Biomed. Apr 2005;18(2):83-103.
  3. Mateescu GD. Functional oxygen-17 magnetic resonance imaging and localized spectroscopy. Adv Exp Med Biol. 2003;510:213-8.

Methods

  1. Yuchi Liu, Yifan Zhang, Chunying Wu, Junqing Zhu, Charlie Wang, Nicholas Tomko, Mikhail D. Linetsky, Robert G. Salomon, Ciro Ramos-Estebanez, Yanming Wang and Xin Yu; High-Resolution Dynamic Oxygen-17 MR Imaging of Mouse Brain With Golden-Ratio-based Radial Sampling and k-Space-Weighted Image Reconstruction, Magn. Reson. Med.; Volume 79, Issue 1 January, 2018, Pages 256–263.
  2. Sebastian C. Niesporek, Reiner Umathum, Jonathan M. Lommen, Nicolas G.R. Behl, Daniel Paech, Peter Bachert, Mark E. Ladd and Armin M. Nagel; Reproducibility of CMRO2 determination using dynamic 17O MRI; Magn Reson Med. 2017 Oct 13. doi:10.1002/mrm.26952
  3. Kurzhunov D, Borowiak R, Reisert M, Krafft AJ, Özen AC, Bock M. 3D CMRO2 mapping in human brain with direct 17O MRI: comparison of conventional and proton-constrained reconstructions. Neuroimage 2017;155:612–624.
  4. Kohsuke Kudo, Taisuke Harada, Hiroyuki Kameda, Ikuko Uwano, Fumio Yamashita, Satomi Higuchi, Kunihiro Yoshioka, Makoto Sasaki; Indirect MRI of 17O-labeled water using steady-state sequences: Signal simulation and preclinical experiment; Magn. Reson. Imaging 2017
  5. Dmitry Kurzhunov, Robert Borowiak, Helge Hass, Philipp Wagner, Axel Joachim Krafft, Jens Timmer, Michael Bock Quantification of Oxygen Metabolic Rates in Human Brain With Dynamic 17O MRI: Profile Likelihood Analysis; Magn Reson Med 2016 Nov 1.
  6. Lou S, Lepak VC, Eberly Le, Roth B, Cui W, Zhu XH, Öz G, Dubinsky JM.; Oxygen consumption deficit in Huntington disease mouse brain under metabolic stress.; Hum Mol Genet. 2016 Jul 1;25(13):2813-2826
  7. Suzuki K, Igarashi H, Huber VJ, Kitaura H, Kwee IL, Nakada T,; Ligand-Based Molecular MRI: O-17 JJVCPE Amyloid Imaging in Transgenic Mice, J NeuroImaging Epub 23 FEB 2014
  8. Zhu XH, Zhang Y, Wiesner HN, Ugurbil K, Chen W,; In Vivo Measurement of CBF Using 17O NMR Signal of Metabolically Produced H217O as a Perfusion Tracer,; Magn Res Medicine 70:309–314 (2013)
  9. Lu M, Zhang Y, Ugurbil K, Chen W, Zhu XH, In Vitro and In Vivo Studies of 17O NMR Sensitivity at 9.4 and 16.4 T,; Magnetic Resonance in Medicine 69:1523–1527 (2013)
  10. Zhu XH, Chen JM, Tu TW, Chen W, Song SK Simultaneous and noninvasive imaging of cerebral oxygen metabolic

rate, blood flow and oxygen extraction fraction in stroke mice, NeuroImage 64:437-447 (2013)

  1. Hoffmann SH, Begovatz P, Nagel AM, et al.; A measurement setup for direct (17) O MRI at 7 T. Magn Reson Med. 2011;66(4):1109-15.
  2. Hyder F.; Dynamic Brain Imaging Multi-Modal Methods and In Vivo Applications. 2009
  3. Zhu XH, Du F, Zhang N, Zhang Y, Lei H, Zhang X, Qiao H, Ugurbil K, Chen W. Advanced In Vivo Heteronuclear MRS Approaches for Studying Brain Bioenergetics Driven by Mitochondria. Methods Mol Biol. 2009;489:317-57.
  4. Mellon EA, Beesam RS, Kasam M, Baumgardner JE, Borthakur A, Witschey WR Jr, Reddy R. Single shot T1rho magnetic resonance imaging of metabolically generated water in vivo. Adv Exp Med Biol. 2009;645:279-86.
  5. de Graaf RA, Brown PB, Rothman DL, Behar KL. Natural abundance 17O NMR spectroscopy of rat brain in vivo. J Magn Reson. 2008;193(1):63-7.
  6. Thelwall PE. Detection of 17O-tagged phosphate by (31)P MRS: a method with potential for in vivo studies of phosphorus metabolism. Magn Reson Med. 2007;57(6):1168-72.
  7. Zhu XH, Zhang Y, Zhang N, Ugurbil K, Chen W. Noninvasive and three-dimensional imaging of CMRO2 in rats at 9.4 T: reproducibility test and normothermia/hypothermia comparison study. J Cereb Blood Flow Metab. 2007; 27: 1225 – 1234.
  8. Tailor DR, Baumgardner JE, Regatte RR, Leigh JS, Reddy R.; Proton MRI of metabolically produced H217O us- ing an efficient 17O2 delivery system. 2004;22(2):611-618.
  9. Sood R. Off-resonance binomial preparatory pulse technique for high sensitivity MRI of H2O-17. Magn Reson Imaging. 2004;22(2):181-195.
  10. Fiat D, Hankiewicz J, Liu S, Trbovic S, Brint S. 17O magnetic resonance imaging of the human brain. Neurol Res. 2004;26(8):803-808.
  11. Zhang X, Zhu XH, Tian R, Zhang Y, Merkle H, Chen W. Measurement of arterial input function of 17O water tracer in rat carotid artery by using a region-defined (REDE) implanted vascular RF coil. 2003;16 (2):77-85.
  12. Zhu XH, Merkle H, Kwag JH, Ugurbil K, Chen W. 17O relaxation time and NMR sensitivity of cerebral water and their field dependence. Magn Reson Med. 2001;45(4):543-9.
  13. Charagundla SR, Duvvuri U, Noyszewski EA, et al. 17O-decoupled (1)H spectroscopy and imaging with a sur- face coil: STEAM decoupling. J Magn Reson. 2000;143(1):39-44.
  14. Reddy R, Stolpen AH, Charagundla SR, Insko EK, Leigh JS. 17O-decoupled 1H detection using a double-tuned coil. Magn Reson Imaging. 1996;14(9):1073-1078.
  15. Reddy R, Stolpen AH, Leigh JS. Detection of 17O by proton T1 rho dispersion imaging. J Magn Reson B.1995;108(3):276-279
  16. Lasker SE. Functional MR imaging of a metabolite of 17O2. Artif Cells Blood Substit Immobil Biotechnol. 1994;22(4):1055-68.
  17. Ronen I, Navon G. A new method for proton detection of H217O with potential applications for functional MRI. Magn Reson Med. 1994;32(6):789-793.
  18. Kwong KK, Xiong J, Kuan WP, Cheng HM. Measurement of water movement in the rabbit eye in vivo using H2 17 Magn Reson Med. 1991;22(2):443-50.
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  20. Hopkins AL, Barr RG. Oxygen-17 compounds as potential NMR T2 contrast agents: enrichment effects of H217O on protein solutions and living tissues. Magn Reson Med. 1987;4(4):399-403.
  21. Yeung HN, Lent AH. Proton transverse relaxation rate of 17O-enriched water. Magn Reson Med. 1987;5(1):87

Brain

  1. Yuchi Liu, Yifan Zhang, Chunying Wu, Junqing Zhu, Charlie Wang, Nicholas Tomko, nMikhail D. Linetsky, Robert G. Salomon, Ciro Ramos-Estebanez, Yanming Wang and Xin Yu; High-Resolution Dynamic Oxygen-17 MR Imaging of Mouse Brain With Golden-Ratio–Based Radial Sampling and k-Space–Weighted Image Reconstruction; Magnetic Resonance in Medicine 79:256–263 (2018)
  2. Marie-Aline Neveu, Nicolas Joudiou, Géraldine De Preter, Jean-Paul Dehoux, Bénédicte F. Jordan1 and Bernard Gallez; 17O MRS assesses the effect of mild hypothermia on oxygen consumption rate in tumors; NMR in Biomedicine, Vol. 30, Issue 8, Aug. 2017
  3. Kohsuke Kudo, Taisuke Harada, Hiroyuki Kameda, Ikuko Uwano, Fumio Yamashita, Satomi Higuchi, Kunihiro Yoshioka, Makoto Sasaki; Indirect Proton MR Imaging and Kinetic Analysis of 17O-Labeled Water Tracer in the Brain; Magn Reson Med Sci 2017; doi:10.2463/mrms.mp.2017-0094
  4. Xiao-Hong Zhu, Wei Chen ; In vivo 17O MRS imaging – Quantitative assessment of regional oxygen consumption and perfusion rates in living brain; Analytical Biochemistry Vol. 529, 15 July 2017, Pages 171-178.
  5. Hannes M. Wiesner, Dávid Z. Balla, G. Shajan, Klaus Scheffler, Kâmil Uğurbil, Wei Chen, Kâmil Uludağ and Rolf; 17O relaxation times in the rat brain at 16.4 tesla; Magnetic Resonance in Medicine Vol. 75, 5, 1886–1893, May 2016
  6. DeLaPaz R, Gupte P.; Potential Application of 17O MRI to Human Ischemic Stroke. Adv Exp Med Biol. 2011;701:22
  7. Mellon EA, Beesam RS, Elliott MA, Reddy R.; Mapping of cerebral oxidative metabolism with MRI. Proc Natl Acad Sci U S A. 2010;107(26):11787-92
  8. Atkinson IC, Sonstegaard R, Pliskin NH, Thulborn KR. Vital signs and cognitive function are not affected by 23Na and 17O magnetic resonance imaging of the human brain at 9.4 T. J Magn Reson Imaging. 2010;32(1):82-7.
  9. Atkinson IC, Thulborn KR. Feasibility of mapping the tissue mass corrected bioscale of cerebral metabolic rate of oxygen consumption using 17-oxygen and 23-sodium MR imaging. 2010;51(2):723-33.
  10. Zhu X-H, Zhang N, Zhang Y, Ugurbil K, Chen W. New insights into central roles of cerebral oxygen metabolism in the resting and stimulus-evoked brain. J Cereb Blood Flow Metab.2009;29(1):10–8.
  11. Mellon EA, Beesam RS, Baumgardner, Borthakur A, Witschey WR, Reddy R. Estimation of the regional cerebral metabolic rate of oxygen consumption with proton detected 17O MRI during precision 17O2 inhalation in swine. J Neurosci Methods.2009;179(1):29-39.
  12. Mellon EA, Beesam RS, Baumgardner JE, Borthakur A, Witschey WR, Reddy R. Estimation of the regional cere- bral metabolic rate of oxygen consumption with MRI during the first 60 seconds of 17O2 inhalation in swine. Intl. Soc. Mag. Reson. Med. 16 (2008).
  13. Zhu XH, Zhang Y, Zhang N, Ugurbil K, Chen W., Noninvasive and three-dimensional imaging of CMRO(2) in rats at 9.4 T: reproducibility test and normothermia/hypothermia comparison study. J. Cereb Blood Flow Metab. 2007;27(6):1225-34
  14. Tailor DR, Roy A, Regatte RR, et al. Indirect 17O-magnetic resonance imaging of cerebral blood flow in the rat. Magn Reson Med. 2003;49(3):479-487.
  15. DeLaPaz RL, Gupte P, Connolly S, Wu E, Brown T. Oxygen-17 Uptake in Mouse Cerebral Ischemia. Intl. Soc. Mag. Reson.Med. 11 (2003).
  16. de Crespigny AJ, D’Arceuil HE, Engelhorn T, Moseley ME. MRI of focal cerebral ischemia using 17O-labeled water. Magn Reson Med. 2000;43(6):876-883.
  17. Ronen I, Merkle H, Ugurbil K, Navon G. Imaging of H217O distribution in the brain of a live rat by using proton-detected 17O MRI. Proc Natl Acad Sci U S A. 1998; 95 (22):12934-12939.
  18. Arai T, Nakao S, Morikawa S, et al. Measurement of local cerebral blood flow by magnetic resonance imaging: in vivo autoradiographic strategy using 17O-labeled water. Brain Res Bull. 1998;45(5):451-456.
  19. Pekar J, Sinnwell T, Ligeti L, Chesnick AS, Frank JA, McLaughlin AC. Simultaneous measurement of cerebral oxy- gen consumption and blood flow using 17O and 19F magnetic resonance imaging. J Cereb Blood Flow Metab. 1995;15(2):312-320.
  20. Fiat D, Dolinsek J, Hankiewicz J, Dujovny M, Ausman J. Determination of regional cerebral oxygen consumption in the human: 17O natural abundance cerebral magnetic resonance imaging and spectroscopy in a whole body system. Neurol Res. 1993;15(4):237-48.
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Miscellaneous

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